Biologic Solutions

The Zimmer Biomet Biologics product portfolio represents the passionate pursuit of the most innovative and clinically relevant solutions addressing the needs of surgeons and their patients. As a leader in autologous therapies, Zimmer Biomet Biologics offers a myriad of solutions for hard tissue applications, including bone grafting products, platelet and plasma concentration systems, a BBMA (blood and bone marrow aspirate) concentration system, an autologous activation system and bone marrow aspiration needles (ancillary products). Also offered are soft tissue management products.

The philosophy defining our hard tissue products is based on the complex process involved in tissue repair, wherein the matrix/scaffold (osteoconductive), signaling proteins (osteopromotive and osteoinductive), and tissue forming cells (osteogenic) work in concert to form new tissue (bone). This “Bone Remodeling Triad” is the cornerstone of the Zimmer Biomet Biologics product portfolio, which is one of the broadest portfolios in the market today. 



The Subchondroplasty®(SCP®) Procedure

The Subchondroplasty® (SCP ®) Procedure is a fluoroscopic, minimally-invasive procedure that targets and fills subchondral bone defects with a hard-setting bone substitute material that is replaced with new bone during the healing process.


Autologous Therapies

Autologous cellular therapies are at the forefront of regenerative medicine.  Such treatment options include blood and bone marrow aspirate and concentration.  Zimmer Biomet offers Platelet-Rich Plasma (PRP) products to produce PRP which can be mixed with autograft or allograft materials to impart better graft-handling characteristics.1


Bone Grafting

Successful bone grafts address each part of the bone healing triad, wherein the matrix/scaffold (osteoconductive), signaling proteins (osteopromotive and osteoinductive), and tissue-forming cells (osteogenic) work in concert to form new tissue (bone).2

Although autograft is considered the gold standard for orthopedic procedures requiring graft material, it has known limitations with associated donor site morbidity and limited availability.3 Synthetic bone graft substitutes have been developed to overcome these limitations of donor site morbidity and limited availability. 



Soft Tissue Management

Zimmer Biomet offers soft tissue management products which may be used in various practices including orthopedics, plastic surgery and general surgery.


Ancillary Products

Zimmer Biomet offers a host of ancillary products which help support and manage the delivery of our extensive product portfolio.

Gel-One Hyaluronate is indicated for the treatment of pain in osteoarthritis (OA) of the knee in patients who have failed to respond adequately to non-pharmacologic therapy, non-steroidal anti-inflammatory drugs (NSAIDs) or simple analgesics, e.g., acetaminophen.

This material is intended for US Health Care Professionals.

Before using Gel-One Hyaluronate, ask your patients if they are allergic to hyaluronan products, cinnamon, or products from birds such as feathers, eggs, and poultry. Gel-One Hyaluronate is only for injection into the knee, performed by a doctor or other qualified health care professional. Gel-One Hyaluronate injection should not be used in the presence of a skin disease or infection around the area where the injection will be given. Gel-One Hyaluronate has not been tested to show pain relief in joints other than the knee and for conditions other than OA. Gel-One Hyaluronate has not been tested in patients who are pregnant, mothers who are nursing, or anyone under the age of 21. Strenuous or prolonged weight-bearing activities after treatment are not recommended. The effectiveness of repeat treatment cycles of Gel-One Hyaluronate has not been established. The side effects most commonly seen after injection of Gel-One Hyaluronate in the clinical trial were knee pain, swelling, and/or knee effusion. These reactions are generally mild and do not last long. For complete instructions for use, see the package insert. 

  1. Lewandrowski et al, Advances in Spinal Fusion – Molecular Science, Biomechanics and Clinical Management, p. 375-389, Marcel Dekker, Inc., 2004.

  2. Hung NN. Basic Knowledge of Bone Grafting. In: Zorzi A, de Miranda JB, eds. Bone Grafting. Rijeka, Croatia: InTech; 2012:11-38.

  3. Khan et al, The Biology of Bone Grafting, J Am Acad Orthop Surg 2005:13:77–86.

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This material is intended for health care professionals. Distribution to any other recipient is prohibited.
For product information, including indications, contraindications, warnings, precautions, potential adverse effects and patient counseling information, see the package insert and information on this website. To obtain a copy of the current Instructions for Use (IFU) for full prescribing and risk information, please call 1-800-348-2759, press 4 for 411 Technical Support.