Adams SB, Yao JQ, Schon LC. Particulated Juvenile Articular
Cartilage Allograft Transplantation for Osteochondral Lesions of the
Talus. Tech Foot Ankle Surg Jun 2011; 10(2):92-98.
A treatment algorithm and detailed description of surgical
technique for treatment of talar lesions with DeNovo NT Graft.
This paper describes 12-month postoperative images of a 24-year-old
male with near complete resolution of talar edema and formation of
Link to Abstract: http://journals.lww.com/techfootankle/Abstract/2011/06000/Particulated_Juvenile_Articular_Cartilage.10.aspx
Bleazy S and Brigido S. Reconstruction of Complex Osteochondral
Lesions of the Talus with Cylindrical Sponge Allograft and
Particulate Juvenile Cartilage Graft: Provisional Results with a
Short-Term Follow up. Foot Ankle Spec Oct 2012; 5:300-305
(first published online Aug 30, 2012).
Retrospective review of 7 patients with full-thickness
cartilage defects treated with medial malleolar osteotomy, subchondral
allograft and DeNovo NT Graft. All 7 patients showed clinically
significant improvement in pain and activity scales 6 months
Link to Abstract: http://fas.sagepub.com/content/5/5/300
Bonner KF, Daner W, Yao JQ. 2-Year Postoperative Evaluation of a
Patient with a Symptomatic Full-Thickness Patellar Cartilage Defect
Repaired with Particulated Juvenile Cartilage Tissue. J Knee
Surg Jun 2010; 23(2):109-14.
Case report of a 36-year-old male with a full-thickness
chondral defect of the patella treated with DeNovo NT Graft. At
2 years postoperative, MRI demonstrates full defect fill and
resolution of subchondral bone edema, and KOOS and IKDC outcomes
scores are substantially improved.
Link to Abstract: http://www.ncbi.nlm.nih.gov/pubmed/21141688
Coetzee JC, Giza E, Schon LC, Berlet GC, Neufeld S, Stone RM,
Wilson EL. Treatment of Osteochondral Lesions of the Talus With
Particulated Juvenile Cartilage. Foot & Ankle Intl, Apr
Case series of 24 ankle surgeries, implanted with DeNovo
NT Graft, for symptomatic chondral lesions. At an average follow up
time of 16 months, 78% had good to excellent scores on the AOFAS scale
with one partial revision.
Link to Abstract: http://fai.sagepub.com/content/early/2013/04/10/1071100713485739.abstract
Cole, B, Farr J, Tabet S, Gold G, Carlson C, Margerrison E.
Clinical, Radiographic and Histological Outcomes following Cartilage
Repair with Particulated Juvenile Articular Cartilage: A 2-Year
Prospective Study. Am J Sports Med, in press
A prospective study of 25 subjects treated with DeNovo NT for
cartilage lesions. Follow up at 2 years post surgery demonstrated
significant improvement in clinical outcome scores, MRI T2 values
approximating normal cartilage, and histology results showing repair
tissue inclusive of hyaline cartilage and excellent integration.
Farr J, Cole B, and Sherman S, Karas V. Particulated Articular
Cartilage: CAIS and DeNovo NT. J Knee Surg Mar 2012; 25(1):23-29.
Review of surgical technique and preliminary data for
DeNovo NT Graft and Cartilage Autograft Implantation System
(CAIS). This paper summarizes previously published findings of
clinical improvement and defect resolution via MRI.
Farr J and Yao JQ. Chondral Defect Repair with Particulated
Juvenile Cartilage Allograft. Cartilage Oct 2011; 2(4):346-353
(first published online Jul 15, 2011).
Case study of 4 patients with chondral lesions of the femoral
condyle or trochlear treated with DeNovo NT Graft. 2-year
follow up demonstrated clinically significant improvements in KOOS,
IKDC subjective and VAS pain scores. MRI showed good defect fill that
persists at least two years.
Link to Abstract: http://car.sagepub.com/content/2/4/346.abstract?rss=1
Hatic SO and Berlet GC. Particulated Juvenile Articular Cartilage
Graft for Treatment of Osteochondral Lesions of the Talus. Foot
Ankle Spec Dec 2010; 3(6):361-364.
A review of treatment options for osteochondral lesions of the
talus and a description of the surgical technique for implanting
DeNovo NT Graft.
Link to Abstract: http://fas.sagepub.com/content/3/6/361
Kruse DL, Ng A, Paden M, Stone PA. Arthroscopic DeNovo NT
Juvenile Allograft Cartilage Implantation in the Talus: A Case
Presentation. J Foot Ankle Surg Mar-Apr 2012; 51(2): 218-21.
A case study of a 30-year-old female with a grade 4 talar
osteochondral lesion treated with DeNovo NT Graft. The patient
was pain free by 6 months postoperation and returned to full activity.
The patient was interviewed again at 24 months postoperation with the
Link to Abstract: http://www.ncbi.nlm.nih.gov/pubmed/22138532
Liu H, Zhao Z, Clarke RB, Gao J, Garrett IR, Margerrison EEC.
Enhanced Tissue Regeneration Potential of Juvenile Articular
Cartilage. AJSM Nov 2013; 41(11):2658-2667.
A comparison of the biological properties and tissue
regeneration capabilities of juvenile and adult bovine articular
cartilage. Results suggest an enhanced regenerative potential of
juvenile cartilage tissue in the restoration of damaged articular
Link to Abstract: http://ajs.sagepub.com/content/early/2013/09/16/0363546513502945
Tompkins M, Hamann JC, Diduch DR, Bonner KF, Hart JM, Gwathmey W,
Milewski MD, Gaskin CM. Preliminary Results of a Novel Single Stage
Cartilage Restoration Technique: Particulated Juvenile Articular
Cartilage Allograft for Chondral Defects of the Patella. Arthroscopy
Oct 2013; 29(10):1661-1670.
Case series of 15 knee surgeries for grade 4 lesions of the
patella treated with DeNovo NT. At an average follow up time of 28
months, the mean fill was 89% and the ICRS cartilage repair assessment
score on MRI was “nearly normal” for all subjects. Clinical outcomes
scores for IKDC and KOOS scales were comparable to those published for
Link to Abstract: http://www.ncbi.nlm.nih.gov/pubmed/23876608