γGamma-bsm® Moldable Putty Bone Substitute Material

Sets hard to create an osteoconductive scaffold

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γGamma-bsm Moldable Putty is a synthetic, biocompatible bone graft substitute material that sets hard and maintains shape at body temperature1. Indicated for bone voids or defects that are not intrinsic to the stability of the bony structure, γGamma-bsm Moldable Putty was developed to meet the need for high compressive strength materials that can be implanted in a wet environment.

  • Provides osteoconductive scaffold for new bone growth while undergoing cell-mediated remodeling as the bone heals2,3,4
  • Nanocrystalline* calcium phosphate is comparable to the mineral composition of human bone2,5
  • Moldable to allow the putty to be placed into open defects created surgically/traumatic injury 
  • Provides 15 minutes of working time to allow for intraoperative flexibility
  • Isothermally sets hard in 3-5 minutes to a compressive strength of 35MPa3, four times strength of cancellous bone6
  • Can be irrigated while setting, and drilled after hardening7
  • Available in single-patient, single-use kits in volumes of 2.5cc, 5cc and 10cc
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*The grain size of the hydroxyapatite (HA) crystals that form as part of the amorphous and crystalline mixture of calcium phosphate sets are on the nanometer scale. The size of the crystalline structures were measured by x-ray diffraction to be less than 100 nanometers.

References

  1. Etex TRE #030731
  2. Tofighi A, Rosenberg A, Sutaria M, Balata S, Chang J. New generation of synthetic, bioresorbable and injectable calcium phosphate bone substitute materials: Alpha-bsm®, Beta-bsm™ and Gamma-bsm™. J Biomimetics, Biomaterials, and Tissue Engineering. 2009.
  3. Sarkar M, Wachter N, Patka P, Kinzl L. First histological observations on the incorporation of a novel calcium phosphate bone substitute material in human cancellous bone.
  4. Rosenberg A, Tofighi A, Camacho N, Chang J. In vitro and in vivo evaluation of calcium phosphate and demineralized bone matrix composite biomaterial. J Biomimetics, Biomaterials, and Tissue Engineering. 5:1-12.
  5. Etex TRE #91001
  6. Van Hvid, Peter Christensen, JøRgen Søndergaard, Peter Brøgger Christensen & Christian Grønhøj Larsen (1983) Compressive Strength of Tibial Cancellous Bone: Instron® and Osteopenetrometer Measurements in an Autopsy Material, Acta Orthopaedica Scandinavica, 54:6, 819-825, DOI: 10.3109/17453678308992915.
  7. Etex TRE 202_144

 

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