N-Force Blue® Bone Substitute Material

N-Force Blue Bone Substitute Material (BSM) is a biomimetic calcium phosphate with similar chemical and physical properties to natural cancellous bone.1–3 It flows readily into cancellous bone, then crystallizes and sets hard in an isothermic reaction at 37˚C to form a macroporous scaffold1. N-Force Blue BSM is replaced with new bone during the healing process.4

N-Force Blue BSM can be used in conjunction with the N-Force Fixation System®.

The N-Force Blue BSM is injected directly into a N-Force® Fenestrated Screw with the use of a sheath, allowing void fill and increasing structural support of the implant.5-6

  • Nanocrystalline* calcium phosphate is comparable to the formulation of human bone mineral N-Force Blue BSM = Ca10-x(M)x(PO4)6-x(HPO4,CO3)x(OH)2-x = Bone*1
  • Can be implanted both by injection through a fenestrated screw, single syringe or molded, which gives the surgeon multiple delivery options
  • Provides an osteoconductive scaffold for new bone growth while undergoing cell-mediated remodeling4 as the bone heals, without sacrificing structure
  • Isothermally sets hard in 10 minutes at an average compressive strength of 7-9MPa.8
  • Slow setting for optimal handling characteristics to reduce the possibility of thermal necrosis development
  • Provides 15 minutes of working time to allow for intraoperative flexibility
*The grain size of the hydroxyapatite (HA) crystals that form as part of the amorphous and crystalline mixture of calcium phosphate sets are on the nanometer scale. The size of the crystalline structures were measured by x-ray diffraction to be less than 100 nanometers.
  1. Knaack D, Goad ME, Aiolova M, Rey C, Tofighi A, Chakravarthy P, Lee DD. Resorbable Calcium Phosphate Bone Substitute. J Biomed Mater Res. 1998 Winter;43(4):399-409.
  2. Colon DA, Yoon BJ, Russell TA, Cammisa FP, Abjornson C. Assessment of the Injection Behavior of Commercially Available Bone BSMs for Subchondroplasty® Procedures. Knee. 2015 Dec;22(6):597-603. doi: 10.1016/j.knee.2015.06.017. Epub 2015 Jul 23.
  3. Hernandez, C.J. Keaveny, T.M. A Biomechanical Perspective on Bone Quality. Bone. 2006 Dec; 39 (6): 1173-1181.
  4. Sarkar MR, Wachter N, Patka P, Kinzl L. First Histological Observations on the Incorporation of a Novel Calcium Phosphate Bone Substitute Material in Human Cancellous Bone. J Biomed Mater Res. 2001 May 1;58(3):329-34.
  5. Zimmer Biomet N-Force Tibia Procedure Animation,  1405.1-GLBL.                         
  6. Zimmer Biomet N-Force Femoral Procedure Animation, 1404.1-GLBL.
  7. Russell TA, Leighton RK; Alpha-BSM Tibial Plateau Fracture Study Group. Comparison of autogenous bone graft and endothermic calcium phosphate cement for defect augmentation in tibial plateau fractures. A multicenter, prospective, randomized study. J Bone Joint Surg Am. 2008 Oct;90(10):2057-61.
  8. TRE_061017


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