rejuvesol (Red Blood Cell Processing) Solution1 is a sterile, non-pyrogenic prescription only solution of sodium pyruvate, inosine, adenine, mono- and dibasic sodium phosphate. rejuvesol Solution is designed for the extracorporeal rejuvenation of a unit of Red Blood Cells (RBC).
- rejuvesol Solution is not for direct administration to
humans
- The only FDA approved rejuvenation solution
restoring 2,3-diphosphoglycerate (2,3-DPG) and adenosine
triphosphate (ATP) of liquid stored RBC concentrate to fresh
levels
- ATP is required to maintain RBC membrane
integrity, flexibility, and deformability, which enables movement
through microvasculature to transport O2 to the
tissues1-4
- rejuvesol Solution is recommended after 14 days of liquid storage (for use in specific FDA approved anticoagulant/storage solution combinations, see the IFU) to restore 2,3-DPG and ATP levels prior to transfusion for immediate use, or to cryopreserve rare blood types or autologous RBCs