Synovasure® Alpha Defensin Test

Introducing Synovasure Alpha Defensin Test for Joint Infection

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The Synovasure Alpha Defensin Test is the first and only test specifically designed and validated for the diagnosis of Joint Infection.  Developed to deliver accuracy, performance and ease of use.

Unparalleled Accuracy

  • The Synovasure Test achieves 97% sensitivity and 96% specificity by measuring synovial fluid alpha defensin1
  • Alpha defensin is an antimicrobial peptide released by neutrophils in response to pathogens
  • Alpha defensin is an ideal biomarker for PJI due to the tremendous separation it achieves between positives and negatives1

Performance backed by data

In the 149 patient study1, the Synovasure Alpha Defensin Test maintained its performance in typically challenging situations such as:

  • Culture Negative Infection

14 of 38 patients with PJI were culture negative and the Synovasure Alpha Defensin Test correctly identified all 14 as infected

  • Systemic Inflammatory Conditions

Synovasure Alpha Defensin Test studies included patients with systemic inflammatory disease and its performance was maintained in this population

  • Antibiotic Therapy

27% of patients with PJI had been treated with antibiotics prior to aspiration and the Synovasure Alpha Defensin Test was not adversely affected in this population

Superior ease of use  

Reference Table

Reference Table
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Legal Manufacturer:

CD Diagnostics
650 Naamans Road
Suite 100
Claymont, DE 19703 USA

 

References

  1. Deirmengian et al. – Combined measurement of synovial fluid alpha-Defensin and C-Reactive Protein levels: highly accurate for diagnosing periprosthetic joint infection. – J Bone Joint Surg Am. 2014;96:1439-45.
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