Refobacin® Bone Cement R

Zimmer Biomet has decades of experience in bone cement. Refobacin® Bone Cement R offers a high viscosity, antibiotic-loaded bone cement, radiopaque and with easy handling.

Reliable Performance

Zimmer Biomet’s bone cements follow the standard specifications in all respects for material used, formulation and manufacturing methods. Bone cements from Zimmer Biomet show reliable performance based on international laboratory standard testing.1,2*

Antibiotic-loaded - broad antibacterial spectrum

Refobacin® Bone Cement R includes gentamicin which has proven to be the antibiotic of choice for bone cement due to its broad antibacterial coverage.3

Refobacin® Bone Cement R includes 0.5 g active gentamicin and provides high local concentrations of gentamicin over several days.4 The protracted release of the antibiotics may protect the implant for an extended period of time, thus reducing the risk of revision.5

Easy Handling

Refobacin® Bone Cement R can be mixed both by hand and in a vacuum mixing system. However, Modern Cementing Technique recommends using a vacuum mixing system such as the ClearMix™ Vacuum Mixers for mixing and delivery of bone cement. This makes standardized handling easy and helps achieve a reproducible, homogeneous bone cement of the highest quality.6,7

High Visibility

Refobacin® Bone Cement R contains chlorophyll and the green coloring improves visualization to surrounding tissue. This cement also provides excellent visualization under post-op x-ray.


* Laboratory testing is not necessarily indicative of clinical performance.

Refobacin® is a trademark licensed from Merck KGaA.

Additional Information

  1. Data on file at Zimmer Biomet, Internal Laboratory Testing, Aug 2016.
  2. ISO 5833, Implants for Surgery – Acrylic Resin Cements (2002).
  3. Gehrke T, et al. Pharmacokinetic study of a gentamicin/clindamycin Bone Cement Used in One-Stage Revision Arthroplasty. In: Bone Cements and Cementing Technique; Walenkamp GHIM, Murray DW, (eds); Springer Verlag Berlin Heidelberg. P 127-134, 2001.
  4. Report Gentamicin Elution, test number 1701-019, issued Feb 2017. Data on file at Zimmer Biomet, Internal Laboratory Testing.
  5. Parvizi J, et al. Efficacy of antibiotic-impregnated cement in total hip replacement. A meta-analysis. Acta Orthopaedica Scandinavica. 79 (3): 335-341, 2008.
  6. Dunne N-J, et al. Influence of the mixing techniques on the physical properties of acrylic bone cement. Biomaterials. 22: 1819-1826, 2001.
  7. Wilkinson J.M., et al. Effect of mixing techniques on the Properties of Acrylic Bone-Cement. The Journal of Arthroplasty. 15:663-667, 2000

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