Redefining Personalization


While you can expect excellent implant survivorship with many of today’s knee replacement systems, studies suggest that one in four patients aren’t fully satisfied with the feel of their new knee.1-3

To create a more natural feel and normal function for patients postoperatively, we believe a system needs to include implants that fit better and instruments designed for ease of use, without the compromises inherent with many systems today.

Persona® The Personalized Knee is our solution featuring personalized implants, precise instrumentation, and proven technology.


While designing the Persona Knee, we used a combination of advanced research tools to study hundreds of knees, creating a global bone atlas. This furthered our understanding of native anatomic shape and function which allowed us to better match our implant shapes and sizes to patients of different ethnicity, gender, and stature.4-5 In a market focused on matching the bone to the implant shape and size, we found that the opposite needed to happen... we need to match the implant to the shape and size of the resected bone.

In doing so, we confirmed that implant shape really matters. Fit really matters. Instrumentation and technology really matters. The Persona Knee was designed with all these elements in mind, because we believe a way to predictably improve patient satisfaction is to more closely reproduce the original. 


Implant shape and fit matter in achieving postoperative patient satisfaction. In designing the Persona Knee, we identified several unmet needs that existed in previous implant designs that we believed, if improved, would help restore a more natural feeling knee and potentially improve patient satisfaction.

A more anatomically accurate implant was identified as one of those needs. While symmetric and asymmetric tibial designs had long since served a purpose, we wanted an implant that fit as close to the native tibia as possible. With that, the Persona Anatomic Tibia was created.

We also believed that the femoral shape should reflect certain characteristics. What was the ethnicity and gender of the patient? Would finer sizing increments help you more closely replace the resected bone? Could we be more bone conserving?

Combine these enhancements with a full continuum of bearing constraints, and you’ll see how the Persona Knee System is redefining personalization.


Patient outcomes can be driven by the precision and accuracy of each step within the surgical procedure. You should expect your instruments to be accurate, but we didn’t want to stop with just being precise. We wanted you to have instruments that feel good in your hand after repetitive use. So we studied the shapes and sizes of the hand to create ergonomic instrumentation.6 We wanted to reduce intraoperative glare from the instruments and make them easier to assemble, so we created a matte finish.

We continued asking ourselves, what issues and decisions do you face intraoperatively. Did you have to sacrifice stability for fit? Why? In what steps would you like better information before proceeding?

By asking these kinds of questions, we were able to design instruments and techniques that allow you to make more informed decisions with each step and provide options for you to personalize each procedure. These options found within the Persona Knee System’s instrumentation were designed to help you consistently achieve optimal outcomes.

Trabecular Metal Material

The Persona Knee System gives you the ability to address the unique needs of each patient with our proven technology. It incorporates an innovative approach designed to improve intraoperative efficiency, patient satisfaction, and long-term survivorship.


                                                      Trabecular Metal™ Material 


Predecessor to the Persona System, the NexGen® Knee System is the most widely used and clinically proven total knee system in the world.7 This, along with the Natural-Knee® II System, created the foundation for what would become the Persona Knee. We took the elements that made the NexGen Knee and Natural-Knee II Systems so successful and looked for ways to further enhance those designs. 

Human Bone Cell

By addressing those opportunities in the Persona Knee, we believe we’ve achieved a big leap forward in total knee arthroplasty, making us very excited about the future of the Persona Knee.

  1. Bourne, R., et al. Patient Satisfaction After Total Knee Arthroplasty: Who Is Satisfied and Who Is Not? Clinical Orthopaedics and Related Research. 468: 57–63; 2010.
  2. Baker, P., et al. The Role of Pain and Function in Determining Patient Satisfaction After Total Knee Replacement. National Registry for England and Wales in Journal of Bone and Joint Surgery (British). 89-B: 893–900; 2007.
  3. Pre-Surgical & Post-Surgical Patient Insights & Needs PPTX. Market Strategies International. March 30, 2009.
  4. Dai, Y., et al. Anatomical Tibial Component Design Can Increase Tibial Coverage and Rotational Alignment Accuracy: A Comparison of Six Contemporary Designs. Knee Surg Sports Traumatol Arthrosc. 22:2911–2923; KSSTA 2014.
  5. Dai, Y., et al. Increased Shape and Size Offerings of Femoral Components Improve Fit During Total Knee Arthroplasty. Knee Surg Sports Traumatol Arthrosc. 22:2931–2940; KSSTA 2014.
  6. Zimmer Biomet Instrumentation Industrial Design Style
  7. Statement based on:
    • 5 million implantations7h
    • 300+ Publications7g
    • 100% Survivorship at 17 Years7a
    • Lowest revision rate7b-e
    • Benchmark for PROMs7f
    • 10A* ODEP rating for CR and PS knees both with and without patella7g
    • Every 90 seconds a patient receives a NexGen knee7h
    • 1 in 5 knees implanted globally is a NexGen Knee7h
  • 7a. Kim, Y.H., et al. Cementless and cemented total knee arthroplasty in patients younger thanfifty five years. Which is better? International Orthopaedics (SICOT) (2014) 38:297–303.
  • 7b. Australian Orthopaedic Association National Joint Replacement Registry. Annual Report. Adelaide.AOA 2016: Table KT9 Cumulative Percent Revision of Primary Total Knee Replacement with Cement Fixation.
  • 7c. Australian Orthopaedic Association National Joint Replacement Registry. Annual Report. Adelaide.AOA 2016: Table KT10 Cumulative Percent Revision of Primary Total Knee Replacement with Cementless Fixation.
  • 7d. Australian Orthopaedic Association National Joint Replacement Registry. Annual Report. Adelaide. AOA 2016: Table KT11 Cumulative Percent Revision of Primary Total Knee Replacement with Hybrid Fixation.
  • 7e. Select variants from the 2016 Swedish National Registry available at (pgs 42-43)
  • 7f. Baker, P.N., et al., The effect of surgical factors on early patient-reported outcome measures (PROMs) following total knee replacement. J Bone Joint Surg Br. 2012;94:1058.
  • 7g. Latest ODEP ratings can be found at
  • 7h. 2016 Sales data available at Zimmer Biomet.
  • 7i. EMBASE search: «NexGen» AND «Knee».


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