While joint replacement can be successful in addressing pain and function, there are no guarantees as to how long the implants will last as variables such as weight and activity level can lead to wear that may require additional surgery to replace the components. Serious complications, such as infection, can occur. Major medical complications, such as heart attack or stroke, are rare, but possible. Each of the following reactions or complications can occur during and/or after surgery and may require medical attention (such as further surgery and/or implant removal):