triCitrasol Anticoagulant Sodium Citrate Concentrate, 46.7% Trisodium Citrate (30.5% free citrate ion), is a sterile, non-pyrogenic solution, used in granulocytapheresis procedures (granulocyte collection by apheresis). Just prior to performing granulocytapheresis, 30 mL of the triCitrasol Concentrate is aseptically added to 500 mL of the solution 6% Hydroxyethyl Starch (HES).
The final solution prevents the coagulation of blood by virtue of the citrate ion's ability to chelate ionized calcium present in the blood to form a non-ionized calcium-citrate complex. When the total dose of citrate ions is greater than the total amount of ionized calcium, clotting is prevented.